2026
Cao, W., Yang, Z., Yi, L., Miao, Y., Zhao, S., Yu, C., Zhou, X., Li, T., Zhou, Y., Lu, T., Jin, J., Wang, T., Zhang, Y., Dou, Y., Fujita, M., Xie, Y., Liu, Y., and Xie, R.,
Lysosomal Aspartylglucosaminidase Couples Glycoprotein Catabolism to Cell-Surface GlycoRNA Production,
bioRxiv 2026.
Bai, J., Geng, D., Chen, X., Li, W., Wang, X., Tian, L., Han, Y., Jin, Z., Du, M., Tang, Y., Hu, W., Zhu, C., Zhang, S., Zhao, Z., Zhang, R., Zhang, X., Kang, W., To, K., Nomura, S., Guo, F., Jiao, S., Xie, Y., Zhou, Z., Dong, C., Li, H., and An, L.,
TGM2-mediated Serotonylation of GPX4 Confers Ferroptosis Resistance to Promote Gastric Tumorigenesis,
Cell Discovery, 12(1), 30, 2026.
Zhao, H., Li, H., Wang, C., Yang, X., Zou, B., Dong, S., Zhang, N., Zhou, Y., Yi, L., Zhang, Y., Xie, Y., Qin, D., Chao, W. C. H., Pei, D., and He, J.,
Chromatin Context-dependent Deacetylation by the Asymmetric Rpd3L,
Nucleic Acids Research, 54(9), gkag443, 2026.
Yu, L., Yi, L., Lu, H., Xie, Y., and Lu, H.,
Mass Spectrometry-based Glycomics towards GlycoRNA,
Glycoscience & Therapy, 2(1), 100021, 2026.
Yi, L., Zhou, Y., Zhang, C., Lu, H., and Xie, Y.,
GlycoRNA Research: from Unknown Unknowns to Known Unknowns,
Protein & Cell, 17(2), 1-20, 2026.
Li, Z., Yu, L., Liu, X., Deng, L., Lin, Z., Liu, Z., Garcia, B. A., and Xie, Y.,
Development of an Immobilized System for RNA Modification Analysis,
Molecular Omics, 22(1), aaiaf005, 2026.
2025
Li, F., Wu, X., Xie, Y., Yang, J., Xi, J., Sun, Y., Chen, J., Wu, X., Huang, S., Zhang, C., Zheng, Y., Li, W., Zuo, X., Li, Y., Chen, K., Lai, X., Liu, X., Zhong, W., Zeng, J., Wu, Q., Garcia, B. A., Lu, H., Xia, H., Zhou, W., and Zhang, Y.,
Nuclear N-Glycosylation Redefines the Glycoscape and Directs Cell Identity,
bioRxiv, 2025.
Zheng, L., Yi, L., Jajosky, R., Kageler, L., Tulin, E., Paz, D., Porat, J., Patel, K., Cummings, R., Xie, Y., Flynn, R. A., and Stowell, S.,
Circulating GlycoRNAs: A Novel Class of Glycoconjugates in Blood and Implications for Erythrocyte Biology,
Blood, 146, 4668, 2025.
Porat, J., Poli, V., Almahayni, K., George, B. M., de Luna Vitorino, F. N., Yi, L., Costa, C. B., Zhou, Y., Crompton, A., Wen, H., Zheng, L., Gregersen, P. K., Agarwal, S., Garcia, B. A., Xie, Y., Möckl, L., Zanoni, I., Simpfendorfer, K. R., and Flynn, R. A.,
DNASE1L3 Surveils Mitochondrial DNA on the Surface of Distinct Mammalian Cells,
bioRxiv, 2025.
Lin, Z., Xie, Y., Gongora, J., Liu, X., Zahn, E., Palai, B. B., Ramirez, D. H., Searfoss, R. M., Vitorino, F. N., Karki, R., Dann, G. P., Zhao, C., Han, X., MacTaggart, B., Lan, X., Fu, D., Greenberg, L., Zhang, Y., Lavine, K. J., Greenberg, M. J., Lv, D., Kashina, A., and Garcia, B. A.,
An Unbiased Proteomic Platform for ATE1-based Arginylation Profiling,
Nature Chemical Biology, 21(12), 1970-1980, 2025.
Zeng, G.-D., Wang, Y.-L., Chen, X.-H., Ma, Y., Zhu, Z., Liu, H.-L., Fan, L.-Y., Nan, H., Nur, Z., Wei, M., Liu, X.-Y., Yi, L., Jin, J.-Y., Cao, Y.-S., Qiu, M.-B., Sun, W.-P., Bai, Y., Zhou, Q.-B., Zhang, G.-Q., Chen, J.-F., Shi, J., Zheng, J., Xie, Y., Li, P., Wan, X.-B., and Fan, X.-J.,
StCEL-based Platform Enables Detection and Sequencing of Native SialoglycoRNA,
bioRxiv, 2025,
Liu, X., Yi, L., Lin, Z., Chen, S., Wang, S., Sheng, Y., Lebrilla, C. B., Garcia, B. A., and Xie, Y.,
Metabolic Control of Glycosylation Forms for Establishing Glycan-Dependent Protein Interaction Networks,
Proceedings of the National Academy of Sciences of the United States of America, 122(25), e2422936122, 2025.
Chen, S., Xie, Y., Alvarez, M. R., Sheng, Y., Bouchibti, Y., Chang, V., and Lebrilla, C. B.,
Quantitative Glycan-Protein Cross-Linking Mass Spectrometry Using Enrichable Linkers Reveals Extensive Glycan-Mediated Protein Interaction Networks,
Analytical Chemistry, 97(3), 1584-1593, 2025.
Xie, Y., Liu, X., Yi, L., Wang, S., Lin, Z., Zhao, C., Chen, S., Robison, F. M., George, B. M., Lebrilla, C. B., Flynn, R. A., and Garcia, B. A.,
Development and Application of GlycanDIA Workflow for Glycomic Analysis,
Nature Communications, 16(1), 7075, 2025.
Prior to Independent Research
Xie, Y., Chai, P., Till, N. A., Hemberger, H., Lebedenko, C. G., Porat, J., Watkins, C. P., Caldwell, R. M., George, B. M., Perr, J., Bertozzi, C. R., Garcia, B. A., and Flynn, R. A., The modified RNA Base acp3U is An Attachment Site for N-glycans in GlycoRNA, Cell, 187(19), 5228–5237.e12, 2024.
Porat, J., Watkins, C. P., Jin, C., Xie, Y., Tan, X., Lebedenko, C. G., Hemberger, H., Shin, W., Chai, P., Collins, J. J., Garcia, B. A., Bojar, D., and Flynn, R. A., O-Glycosylation Contributes to Mammalian GlycoRNA Biogenesis, bioRxiv, 2024.
Liu, X., Zhang, Y., Wen, Z., Hao, Y., Banks, C. A. S., Cesare, J., Bhattacharya, S., Arvindekar, S., Lange, J. J., Xie, Y., Garcia, B. A., Slaughter, B. D., Unruh, J. R., Viswanath, S., Florens, L., Workman, J. L., and Washburn, M. P., An Integrated Structural Model of the DNA Damage-Responsive H3K4me3 Binding WDR76:SPIN1 Complex with the Nucleosome, Proceedings of the National Academy of Sciences of the United States of America, 121(33), e2318601121, 2024.
Izadifar, Z., Cotton, J., Chen, S., Horvath, V., Stejskalova, A., Gulati, A., LoGrande, N. T., Budnik, B., Shahriar, S., Doherty, E. R., Xie, Y., To, T., Gilpin, S. E., Sesay, A. M., Goyal, G., Lebrilla, C. B., and Ingber, D. E., Mucus Production, Host-Microbiome Interactions, Hormone Sensitivity, and Innate Immune Responses Modeled in Human Cervix Chips, Nature Communications, 15(1), 4578, 2024.
Xie, Y., Chen, S., Alvarez, M. R., Sheng, Y., Li, Q., Maverakis, E., and Lebrilla, C. B.,
Protein Oxidation of Fucose Environments (POFE) Reveals Fucose-Protein Interactions,
Chemical Science, 15(14), 5256–5267, 2024.
Frisbie, V. S., Hashimoto, H., Xie, Y., De Luna Vitorino, F. N., Baeza, J., Nguyen, T., Yuan, Z., Kiselar, J., Garcia, B. A., and Debler, E. W.,
Two DOT1 Enzymes Cooperatively Mediate Efficient Ubiquitin-Independent Histone H3 Lysine 76 Tri-Methylation in Kinetoplastids,
Nature Communications, 15(1), 2467, 2024.
Lin, Z., Gongora, J., Liu, X., Xie, Y., Zhao, C., Lv, D., and Garcia, B. A.,
Automation to Enable High-Throughput Chemical Proteomics,
Journal of Proteome Research, 22(12), 3676–3682, 2023.
Lu-Culligan, W. J., Connor, L. J., Xie, Y., Ekundayo, B. E., Rose, B. T., Machyna, M., Pintado-Urbanc, A. P., Zimmer, J. T., Vock, I. W., Bhanu, N. V., King, M. C., Garcia, B. A., Bleichert, F., and Simon, M. D.,
Acetyl-methyllysine Marks Chromatin at Active Transcription Start Sites,
Nature, 622(7981), 173–179, 2023.
Chen, S., Bouchibti, Y., Xie, Y., Chen, Y., Chang, V., and Lebrilla, C. B.,
Analysis of Cell Glycogen with Quantitation and Determination of Branching Using Liquid Chromatography-Mass Spectrometry,
Analytical Chemistry, 95(34), 12884–12892, 2023.
Lauman, R., Kim, H. J., Pino, L. K., Scacchetti, A., Xie, Y., Robison, F., Sidoli, S., Bonasio, R., and Garcia, B. A., Expanding the Epitranscriptomic RNA Sequencing and Modification Mapping Mass Spectrometry Toolbox with Field Asymmetric Waveform Ion Mobility and Electrochemical Elution Liquid Chromatography, Analytical Chemistry, 95(12), 5187–5195, 2023.
Alvarez, M. R., Zhou, Q., Tena, J., Barboza, M., Wong, M., Xie, Y., Lebrilla, C. B., Cabanatan, M., Barzaga, M. T., Tan-Liu, N., Heralde, F. M., 3rd, Serrano, L., Nacario, R. C., and Completo, G. C., Glycomic, Glycoproteomic, and Proteomic Profiling of Philippine Lung Cancer and Peritumoral Tissues: Case Series Study of Patients Stages I–III, Cancers, 15(5), 1559, 2023.
Xie, Y., De Luna Vitorino, F. N., Chen, Y., Lempiäinen, J. K., Zhao, C., Steinbock, R. T., Lin, Z., Liu, X., Zahn, E., Garcia, A. L., Weitzman, M. D., and Garcia, B. A., SWAMNA: A Comprehensive Platform for Analysis of Nucleic Acid Modifications, Chemical Communications, 59(83), 12499–12502, 2023.
Merleev, A. A., Le, S. T., Alexanian, C., Toussi, A., Xie, Y., Marusina, A. I., Watkins, S. M., Patel, F., Billi, A. C., Wiedemann, J., Izumiya, Y., Kumar, A., Uppala, R., Kahlenberg, J. M., Liu, F. T., Adamopoulos, I. E., Wang, E. A., Ma, C., Cheng, M. Y., Xiong, H., and Maverakis, E., Biogeographic and Disease-Specific Alterations in Epidermal Lipid Composition and Single-Cell Analysis of Acral Keratinocytes, JCI Insight, 7(16), e159762, 2022.
Xie, Y., Janssen, K. A., Scacchetti, A., Porter, E. G., Lin, Z., Bonasio, R., and Garcia, B. A., Permethylation of Ribonucleosides Provides Enhanced Mass Spectrometry Quantification of Post-Transcriptional RNA Modifications, Analytical Chemistry, 94(20), 7246–7254, 2022.
Janssen, K. A., Xie, Y., Kramer, M. C., Gregory, B. D., and Garcia, B. A., Data-Independent Acquisition for the Detection of Mononucleoside RNA Modifications by Mass Spectrometry, Journal of the American Society for Mass Spectrometry, 33(5), 885–893, 2022.
Sheng, Y., Vinjamuri, A., Alvarez, M. R. S., Xie, Y., McGrath, M., Chen, S., Barboza, M., Frieman, M., and Lebrilla, C. B., Host Cell Glycocalyx Remodeling Reveals SARS-CoV-2 Spike Protein Glycomic Binding Sites, Frontiers in Molecular Biosciences, 9, 799703, 2022.
Li, Q., Xie, Y., Rice, R., Maverakis, E., and Lebrilla, C. B. 2022, A Proximity Labeling Method for Protein-Protein Interactions on Cell Membrane, Chemical Science, 13(20), 6028–6038, 2022.
Kim, T., Xie, Y., Li, Q., Artegoitia, V. M., Lebrilla, C. B., Keim, N. L., Adams, S. H.,and Krishnan, S., Diet Affects Glycosylation of Serum Proteins in Women at Risk for Cardiometabolic Disease, European Journal of Nutrition, 60(7), 3727–3741, 2021.
Zhou, Q., Xie, Y., Lam, M., and Lebrilla, C. B., N-Glycomic Analysis of the Cell Shows Specific Effects of Glycosyl Transferase Inhibitors, Cells, 10(9), 2318, 2021.
Maverakis, E., Merleev, A. A., Park, D., Kailemia, M. J., Xu, G., Ruhaak, L. R., Kim, K., Hong, Q., Li, Q., Leung, P., Liakos, W., Wan, Y. Y., Bowlus, C. L., Marusina, A. I., Lal, N. N., Xie, Y., Luxardi, G., and Lebrilla, C. B., Glycan Biomarkers of Autoimmunity and Bile Acid-Associated Alterations of the Human Glycome: Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis-Specific Glycans, Clinical Immunology, 230, 108825, 2021.
Zheng, J. J., Agus, J. K., Hong, B. V., Tang, X., Rhodes, C. H., Houts, H. E., Zhu, C., Kang, J. W., Wong, M., Xie, Y., Lebrilla, C. B., Mallick, E., Witwer, K. W., and Zivkovic, A. M., Isolation of HDL by Sequential Flotation Ultracentrifugation Followed by Size Exclusion Chromatography Reveals Size-Based Enrichment of HDL-Associated Proteins, Scientific Reports, 11(1), 16086, 2021.
Xie, Y., Chen, S., Li, Q., Sheng, Y., Alvarez, M. R., Reyes, J., Xu, G., Solakyildirim, K., and Lebrilla, C. B., Glycan-Protein Cross-Linking Mass Spectrometry Reveals Sialic Acid-Mediated Protein Networks on Cell Surfaces, Chemical Science, 12(25), 8767–8777, 2021.
Kasper, D. M., Hintzen, J., Wu, Y., Ghersi, J. J., Mandl, H. K., Salinas, K. E., Armero, W., He, Z., Sheng, Y., Xie, Y., Heindel, D. W., Park, E. J., Sessa, W. C., Mahal, L. K., Lebrilla, C., Hirschi, K. K., and Nicoli, S., The N-Glycome Regulates the Endothelial-to-Hematopoietic Transition, Science, 370(6521), 1186–1191, 2020.
Merleev, A. A., Le, S. T., Alexanian, C., Toussi, A., Xie, Y., Marusina, A. I., Watkins, S. M., Patel, F., Billi, A. C., Wiedemann, J., Izumiya, Y., Kumar, A., Uppala, R., Kahlenberg, J. M., Liu, F.-T., Adamopoulos, I. E., Wang, E. A., Ma, C., Cheng, M. Y., Xiong, H., Kirane, A., Luxardi, G., Andersen, B., Tsoi, L. C., Lebrilla, C. B., Gudjonsson, J. E., and Maverakis, E., A Site-Specific Map of the Human Plasma Glycome and Its Age and Gender-Associated Alterations, Scientific Reports, 10(1), 17505, 2020.
Park, S., Doherty, E. E., Xie, Y., Padyana, A. K., Fang, F., Zhang, Y., Karki, A., Lebrilla, C. B., Siegel, J. B., and Beal, P. A., High-Throughput Mutagenesis Reveals Unique Structural Features of Human ADAR1, Nature Communications, 11(1), 5130, 2020.
Li, Q., Xie, Y., Wong, M., Barboza, M., and Lebrilla, C. B., Comprehensive Structural Glycomic Characterization of the Glycocalyxes of Cells and Tissues, Nature Protocols, 15(8), 2668–2704, 2020.
Xie, Y., Sheng, Y., Li, Q., Ju, S., Reyes, J., and Lebrilla, C. B., Determination of the Glycoprotein Specificity of Lectins on Cell Membranes Through Oxidative Proteomics, Chemical Science, 11(35), 9501–9512, 2020.
Li, Q., Xie, Y., Wong, M., and Lebrilla, C. B., Characterization of Cell Glycocalyx with Mass Spectrometry Methods, Cells, 8(8), 882, 2019.
Li, Q., Xie, Y., Xu, G., and Lebrilla, C. B., Identification of Potential Sialic Acid Binding Proteins on Cell Membranes by Proximity Chemical Labeling, Chemical Science, 10(24), 6199–6209, 2019.
Xie, Y., Peng, C., Gao, Y., Liu, X., Liu, T., and Joy, A., Mannose-Based Graft Polyesters with Tunable Binding Affinity to Concanavalin A, Journal of Polymer Science Part A: Polymer Chemistry, 55, 3908-3917, 2017.
